6th sunrise meeting : Heterogeneity and Plasticity in cancer>

Programme > Full Programme

Day 1: Tuesday, May 26th
08:15 - 08:45 Registration and Welcome Coffee
Opening Keynote Opening words (President: Christophe Ginestier) | Chair: Raphael Rodriguez
09:00 Mark DAWSON (Peter MacCallum Cancer Centre, Australia) Genetic and non-genetic mechanisms of clonal dominance and therapeutic resistance in cancer
Tumor Evolution 1, part 1 Chairs: Thomas Daubon and Laura Jentschel
10:00 Simona PARINELLO (UCL, UK) The role of injury programmes in gliomagenesis.
10:30
Selected Abstracts
Justine Marsolier (Inst. Curie, Paris, France) Understanding & fighting drug persistence in breast cancer
Min Wu (CRCM, Marseille, France) Temporal dynamics of IRF1 functional dependency in chemotherapy-induced drug-tolerant persister cells of triple-negative breast cancer
11:00 **BREAK**: Coffee break and exhibition visit LaboGreenpharma Logo
Tumor Evolution 1, part 2 Chairs: Thomas Pradeu and Shuheng Lin
11:30 Carlo C. MALEY (Arizona, USA) Evolutionary measures of intra-tumor heterogeneity
12:00 Alejo RODRIGUEZ-FRATICELLI (IRB, Barcelona) Tracing stem cell heterogeneity across lifespan: development, aging and leukemia
12:30 **LUNCH**: Lunch break, Posters & exhibition visit
13:30 - 14:30 **POSTER SESSION 1**: 1st Poster Session
Tumor Evolution 2 Chairs: Christophe Ginestier and Guillaume Belthier
14:30 Francesco NICASSIO (Milano, Italy) Decoding Cancer Stem Cell Plasticity through Single-Cell Multi-Omics and Long-Read Transcriptomics
15:00
Selected Abstracts
Aurore Aguado (IGR, Villejuif, France) Mitochondrial transfer and cell reprogramming in ovarian cancer
Laurie Clauzon (Univ. Palermo, Palermo, Italy) Epithelial–Mesenchymal Plasticity underlies adaptive resistance to FLOT chemotherapy in Esophageal Adenocarcinoma
15:30 Eric LETOUZÉ (CRCI2NA, Nantes) Single-cell profiling of tumor ecosystems uncovers mechanisms of resistance and predictors of treatment response
16:00 **BREAK**: Coffee Break and exhibition visit
Pediatric Oncology Session (React4Kids) React4Kids Logo Chairs: Aurelia Huyghe and Barbara Yael Braz
16:30 Richard J. GILBERTSON (Cambridge, UK) Haematopoietic stem cells instruct childhood brain tumour immunotolerance
17:00
Selected Abstracts
Camila Castillo Ferrer (CRCL, Lyon, France) Metastatic neuroblastoma cells adopt a diapause-like dormant state stemming from their embryonic origin
Marco Bruschi (IGR, Villejuif, France) Modelling the genetic susceptibility to pediatric choroid plexus tumors with iPSC-derived neural organoids
17:30 Cecile THIRANT (Inst. Curie, France) Unraveling the mechanisms regulating tumor cell plasticity and identity in Neuroblastoma
18:00 - 19:00 **SOCIAL EVENT**: **POSTER SESSION 2**: 2nd Poster Session and Ice Breaking Drink
Day 2: Wednesday, May 27th
FSSCR Session FSSCR Logo Chairs: Thierry Virolle and Vincent Guen
09:00 Pierre CHYMKOWITCH (University of Oslo, Norway) SUMOylation Preserves Epigenetic Fate and Facilitates Control of Lineage Potential in Human Adipose Stem Cells
09:30 Shuheng Lin (CRCM, Marseille, France) A Novel Lineage-Tracing System to Reconstruct the Early Steps of Breast Tumorigenesis
09:45 Pierre-Antoine DEFOSSEZ (Epigenetics and cell fate, Paris) DNA methylation protects cancer cells against senescence
Meet the Editor Session
10:15 Laura Sanchez Burgos, PhD Senior Editor at Nature Communications
10:45 **BREAK**: Coffee Break and exhibition visit
Tumor Ecosystem Chairs: Caroline Bonnans and Tina Lahlou
11:15 Julie GIRAUD Immunosuppressive myeloid cells promote cancer stemness in hepatocellular carcinoma
11:45
Selected Abstracts
Britt Vervoort (Princess Maxima Centrum, Netherlands) Unravelling heterogeneity in response to engineered T-cell immunotherapy using patient-derived organoids
Sophie Mouillet-Richard (CRC, Paris, France) Profiling colon cancer architecture with spatial transcriptomics identifies clinically relevant stromal ecotypes
12:15 Sponsor Talk Singleron LogoSingleron Biotechnologies : Advanced Single Cell Sequencing Technologies (Diego Amarante da Silva)
12:30 Anne RIOS
13:00 - 18:00 **FREE AFTERNOON**: Social events (free of science afternoon)
Find activities in Bordeaux →
19:00 Gala Diner - Tchanqué
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Day 3: Thursday, May 28th
Targeting Tumor Heterogeneity & Metastatic Dissemination 1 Chairs: Julie Pannequin and Lena Marie Schmidt
10:00 Juliane WINKLER (Vienna, Austria) Dissecting tumor and immune cell heterogeneity in breast cancer metastasis
10:30
Selected Abstracts
Laura Soumoy (IGR, Villejuif, France) Translational control of MIF secretion drives immune evasion in melanoma persister cells
Camille Tessier (CRCI2NA, Nantes, France) Targeting primary ciliogenesis to intercept EMT-induced cancer cell plasticity
11:00 Eduard BATLLE (IRB, Barcelona) Tumor Cell Plasticity in Metastatic Colorectal Cancer
11:45 Thomas DAUBON (IBGC, Bordeaux) How glioblastoma cells adapt their metabolism when they meet their neighbors ?
12:15 **LUNCH**: Lunch break & exhibition visit
Targeting Tumor Heterogeneity & Metastatic Dissemination 2 Chairs: Emmanuelle Charafe-Jauffret and Maria Haykal
13:30 Christopher TAPE (UCL cancer institute, UK) Targeting Tumor Heterogeneity 2: Single-cell Phenoscaping of Tumour Microenvironment Organoids
14:00
Selected Abstracts
Laura Jentschel (IGF, Montpellier, France) Chemotherapy-Induced Translational Upregulation of IL-8 Drives Exit from Drug-Tolerant Persistence and Tumor Relapse
Gorann Lepied (Univ. Bordeaux, Bordeaux, France) Development of multivalent aptamers for gastric cancer stem cells targeting
14:30 Raphael RODRIGUEZ (Curie, Paris) Chemical control of cell adaptation
15:00 **CLOSING** Poster & Oral Presentation
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